Can you take Tagamet with blood thinners?
Tagamet may interact with blood thinners, clopidogrel, phenytoin, nifedipine, metronidazole, propranolol, chlordiazepoxide, lidocaine, diazepam, theophylline, depression or anxiety medications. Tell your doctor all medications you use.
How does cimetidine interact with warfarin?
Substituted imidazoles like cimetidine inhibit hepatic microsomal activity, which may cause reduced metabolic clearance of warfarin and augment its anticoagulant effect. Ranitidine, lacking these effects, may be safer for patients undergoing anticoagulation who require H2-receptor antagonists.
Can you take antacids with Coumadin?
Ask your doctor before taking antacids if you: Have kidney or liver problems. Are on a low-sodium diet. Are taking thyroid medication — such as Levoxyl or Synthroid (levothyroxine) — or the blood thinner Coumadin or Jantoven (warfarin), since antacids may interfere with these drugs.
Do Antacids interact with warfarin?
Common drugs that can interact with warfarin include: Aspirin or aspirin-containing products. Acetaminophen (Tylenol, others) or acetaminophen-containing products. Antacids or laxatives.
Does Tagamet interfere with levothyroxine?
Reassuring news from a large clinical trial though: drugs that did not affect TSH in people taking levothyroxine were glucocorticoids (steroids) or the H2 receptor antagonists (Pepcid, Zantac, Tagamet, etc).
How does rifampin affect warfarin?
Rifampin’s concomitant use with warfarin results in a clinically significant drug–drug interaction. This interaction leads to accelerated warfarin’s clearance and ultimately a reduction in its anticoagulant effect (Strayhorn et al.
What drugs do cimetidine interact with?
Some products that may interact with this drug include: cisapride, dofetilide, epirubicin, ticlopidine, artemether, clopidogrel, lumefantrine, metformin, moclobemide, moricizine, quinidine, silver sulfadiazine.
Why is Coumadin being discontinued?
The manufacturing of all strengths of Coumadin (warfarin sodium) tablets has been discontinued. As announced by Bristol-Myers Squibb, Coumadin’s manufacturer, the discontinuation is due to an unexpected manufacturing issue, not because of safety or efficacy issues.
How does cimetidine inhibit cytochrome P450?
Cimetidine increases plasma levels of warfarin and acenocoumarol by inhibiting cytochrome P450-dependent metabolism. Cimetidine increases plasma levels (e.g., phenytoin, carbamazepine) by inhibiting cytochrome P450-dependent metabolism.
