What is the normal range for C1 esterase inhibitor?
Normal levels of C1-INH generally range from 16 to 33 milligrams per deciliter. If your C1-INH levels are lower or higher than normal, it may be a sign of: hereditary or acquired angioedema. SLE.
What deficiency causes hereditary angioedema?
The symptoms of hereditary angioedema type I develop due to a deficiency of a protein known as complement component C1 esterase inhibitor. Hereditary angioedema type II is a more uncommon form of the disorder and may occur because of abnormal C1 esterase proteins that do not function properly.
What does C1 mean in a blood test?
C1 esterase inhibitor (C1-INH) is a protein found in the fluid part of your blood. It controls a protein called C1, which is part of the complement system. The complement system is a group of nearly 60 proteins in blood plasma or on the surface of some cells.
What are the symptoms of angioedema?
Common Symptoms
- Swelling: The hallmark of angioedema is swelling and puffiness of the eyes or lips.
- Redness: Redness can accompany the swelling or may appear on its own.
- Rash: A rash, which may appear as small bumps or flat areas clustered together, can develop anywhere on the skin and is usually reddish.
Why does C1 esterase deficiency cause angioedema?
C1 esterase inhibitor deficiency, also known as hereditary angioedema, results in the unchecked production of the vasodilator bradykinin.
Is angioedema considered an autoimmune disease?
It is caused by the deficiency of CI esterase inhibitor. Hereditary angioedema may be associated with autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroiditis and glomerulonephritis.
Can low thyroid cause angioedema?
Severe hypothyroidism can manifest with puffiness of the face and lips very similar to angioedema (fig. 6).
